Advanced Drug Delivery Reviews

Advanced Drug Delivery Reviews

The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery.

In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand.

Articles review the current status of a specific topic, giving equal emphasis to the identification of major conceptual and technological challenges to successful drug and gene delivery, to an evaluation of triumphs as well as shortcomings in current conceptual and technical approaches, and to a discussion of their possible solution.

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Volume 60, Issue 1, Pages 1-88 (3 January 2008)

Peptide and Protein PEGylation III: Advances in Chemistry and Clinical Applications
Edited by Francesco M. Veronese and J. Milton Harris
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1.Editorial Page ii
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Peptide and protein PEGylation III: advances in chemistry and clinical applications
Pages 1-2
Francesco M. Veronese, J. Milton Harris
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Disulfide bridge based PEGylation of proteins
Pages 3-12
Steve Brocchini, Antony Godwin, Sibu Balan, Ji-won Choi, Mire Zloh, Sunil Shaunak
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Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase
Pages 13-28
Angelo Fontana, Barbara Spolaore, Anna Mero, Francesco M. Veronese
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Releasable PEGylation of proteins with customized linkers
Pages 29-49
David Filpula, Hong Zhao
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Formulation of Neulasta® (pegfilgrastim)
Pages 50-58
Deirdre Murphy Piedmonte, Michael J. Treuheit
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PEG-uricase in the management of treatment-resistant gout and hyperuricemia
Pages 59-68
Merry R. Sherman, Mark G.P. Saifer, Fernando Perez-Ruiz
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Anti-cancer PEG-enzymes: 30 years old, but still a current approach
Pages 69-78
Gianfranco Pasut, Mauro Sergi, Francesco M. Veronese
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PEGylation of cyanovirin–N, an entry inhibitor of HIV
Pages 79-87
H. Zappe, M.E. Snell, M.J. Bossard
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